Foly 15 Tablet | Epharma Medicine
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Foly 15 Tablet 14pcs

Generic: Folinic Acid

Type: Tablet

Pack Size: 14 pcs

Calcium Folinate is metabolized into 5-methyltetrahydrofolate, which:

  1. Neutralizes Methotrexate Effects: Supplies the cofactor blocked by methotrexate.
  2. Enhances Fluorouracil Activity: Stabilizes the binding of 5-dUMP with thymidylate synthetase.
  3. Counteracts Folic Acid Antagonists: Neutralizes toxic effects of methotrexate while enhancing 5-fluorouracil efficacy.

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MRP: ৳ 350 5% Off

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✅ Description:

Foly 15mg contains Calcium Folinate, which is essential for the synthesis of purine and pyrimidine, aiding in the production of blood and its components. It serves as a coenzyme in numerous metabolic systems and is especially effective in countering the toxicity of methotrexate and in treating folate deficiency-related conditions.

  1. Colorectal Cancer: As an adjunct to enhance the efficacy of fluorouracil.
  2. Methotrexate Toxicity: Antidote to prevent or reverse toxicity caused by methotrexate.
  3. Megaloblastic Anemia: Particularly anemia caused by folate deficiency.
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Relevant Products / প্রাসঙ্গিক পণ্য

✔️ Methotrexate Toxicity:
  • Adults: 15 mg every 6 hours for 10 doses. Start 24 hours after initiating methotrexate infusion. Continue until methotrexate serum levels drop below 0.05 micromolar.

Megaloblastic Anemia (Folate Deficiency):

  • Adults: 15 mg daily.
✔️ Side Effects
  • Common: Rash, pruritus, erythema, urticaria, nausea, vomiting, fever (pyrexia).
  • Allergic Sensitization: Possible with rash and skin irritation.
✔️ Drug Interactions

Fluorouracil:

  • Calcium Folinate increases fluorouracil's efficacy but may also enhance its toxicity.
  • Severe Adverse Effects: Enterocolitis, diarrhea, dehydration (especially in elderly patients).

Sulfamethoxazole-Trimethoprim:

  • Calcium Folinate can reduce its efficacy in treating Pneumocystis carinii pneumonia in AIDS patients.
✔️ Contraindications
  • Hypersensitivity: To Calcium Folinate or its components.
  • Vitamin B12 Deficiency-Related Anemias: Such as pernicious anemia or megaloblastic anemia caused by Vitamin B12 deficiency.
  • Intrathecal/Intraventricular Administration: Strictly contraindicated.
✔️ Notes:
  • Avoid excessive use of folate supplements or folinic acid without a doctor’s recommendation, as it may interfere with necessary therapies (e.g., methotrexate).
  • Patients with AIDS or compromised immune systems must be monitored closely for potential drug interactions.
✔️
  1. Undiagnosed Megaloblastic Anemia: May obscure diagnosis and delay appropriate treatment.
  2. Folate-Dependent Tumors: Caution in such patients.
  3. Pregnancy: Use only when the benefits outweigh the risks.
  4. Gastrointestinal Toxicity: Administer parenterally if the patient experiences severe nausea, vomiting, or GI toxicity.
  5. Monitoring:
    • Calcium Levels: For patients receiving combined 5-Fluorouracil and Folinic Acid treatment.
    • Methotrexate Serum Levels: Determine the optimal dose and duration of Folinic Acid therapy.
    • CBC, Electrolytes, and Liver Function Tests: Before and during treatment.
✔️ Storage
  • Store below 30°C.
  • Keep away from direct light and out of reach of children.
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Check our pricing section for Foly 15 Tablet 14pcs price in Bangladesh. After Submitting Order, You may receive phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

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